Five University of Bristol spinout companies with links to the Bristol BioDesign Institute and BrisSynBio have announced over £4m in new investment and awards.
Halo Therapeutics secured a £1.5 million investment, led by the Development Bank of Wales alongside Science Angel Syndicate (SAS) members and the KBA Group, to begin clinical trials of an easy-to-use, cost-effective, home therapeutic treatment for SARS-CoV-2 (coronaviruses). Halo was founded by CEO Dr Daniel Fitzgerald, Prof Christiane Berger-Schaffitzel, and Prof Imre Berger following research conducted as part of BrisSynBio. Imre, a Co-Director of the BBI, said the antiviral spray: “stops the virus from entering and multiplying in the nasal epithelial cells, where it can then spread to the throat and then into the lungs. It is a potential game-changer in the treatment and prevention of coronaviruses, particularly with the emergence of new viruses.”
Scarlet Therapeutics, which is working on a new technology to develop red blood cells that carry additional proteins within them to provide therapeutic benefit which can reach all parts of the body, has received funding to progress the innovation. Founded by Prof Ash Toye and Prof Jan Frayne, Scarlet Therapeutics has raised seed funding from Science Creates Ventures and Meltwind to build a pipeline of novel therapies to treat patients with a wide range of diseases, particularly metabolic disorders.
Rosa Biotech has secured £415,000 in Seed+ investment to accelerate development of its pioneering bio-sensing technology, designed to enable cost effective screening of a range of life-threatening diseases with high accuracy at an early stage. Rosa is initially targeting “the early identification of non-alcoholic fatty liver disease (NAFLD) which, if left untreated can develop into steatohepatitis (NASH) leading to liver failure. The Western world has experienced a 100% increase in NASH cases during the last 30 years and this trend is expected to accelerate in the coming decades.”
CDotBio, which is cultivating novel carbon nanodot biotechnology for a new generation of efficient, productive, climate resilient crops, has been awarded £50,000 from the Blavatnik Prize for Innovation. The Prize “provides opportunities for start-ups, pre-registration teams, or individuals to launch a bespoke project that would support the commercialisation of their technologies or products”.
Congratulations to Veronica Greco, Dora Buzas and Jazz Ghataora for successfully completing their PhD vivas.
Jazz Ghataora’s PhD research focused on the development of bacterial biosensors for the purpose of monitoring environmental heavy metal pollution, using the host Bacillus subtilis as a chassis. This project required the design of synthetic gene circuits, novel engineered chimeric proteins and structure guided mutagenesis. His supervisors were Prof. Susanne Gebhard and Dr. Bianca Reeksting. Jazz, a Research Associate in the BioCompute Lab at University of Bristol, is currently researching next generation reporter tags for yeast platform strain development as part of the BrisEngBio project ‘Nanopore-based physiological monitoring of yeast for bioprocess optimisation’, led by BBI Co-Director Thomas Gorochowski, and University of Washington’s Jeff Nivala.
Veronica Greco‘s PhD thesis title was: ‘Recombinase-based cellular memory: Methods for reading and reliable writing as steps towards real-world applications.’ She was supervised by Dr. Thomas Gorochowski and Professor Claire Grierson. Veronica is the Technology and Innovation Manager at CDotBio.
The School of Biochemistry was delighted to host Thangam Debbonaire, Labour MP for Bristol West and Shadow Leader of the House of Commons, on 9 June 2023.
Thangam toured the labs of Mark Dodding and BBI Director Dek Woolfson, where group members demonstrated their experiments to visualise motor protein activity in vitro and inside cells.
Jessica and Thangam were joined by VC Evelyn Welch and researchers Laura O’Regan, Kate Kurgan, Bernadette Carroll, Rachel Curnock, Kirsty McMillan and Emma Jones for lunch. It was a welcome opportunity to celebrate the contributions of women in science and to address barriers for women following careers in STEM.
Congratulations to Dr Jessica Cross, an ESPRC Doctoral Prize Fellow working in the Dodding/Woolfson labs, for making the shortlist of the L’Oreal-UNESCO For Women in Science Rising Talent Program, and being one of two highly commended applicants in the Physical Sciences category. Jessica visited 10 Downing Street, where she met George Freeman MP (Minister of State for Science, Research & Innovation), and has attended a training day for shortlisted candidates at the Royal Society, and a reception at the House of Commons.
Among the 170 attendees at the reception were MPs, academics and representatives from L’Oréal and UNESCO. These events have given Jessica and the others the chance to showcase their research, raise awareness of the important contribution of women in science, and discuss barriers for women in STEM and the need for policy change.
Jessica said: “I am pleased and honoured to be recognised as a highly commended candidate by the L’Oreal UNESCO For Women in Science Program. It has been a fantastic opportunity to share our research and to network with inspiring women in science. This program is a good example of showcasing female talent in science and offering role models to the next generation of science leaders.”
As part of the ADDovenom team, the post-holder will utilize state-of-the-art selection/evolution technology (Ribosome Display) to generate high-affinity binders (nanobodies and new scaffold proteins) that neutralise snake venom toxins. This project to develop new, safe and efficient antivenom to treat snakebites is an international collaboration with Liverpool School of Tropical Medicine, University of Liege, University of Aix-Marseille, and iBET.
Experience with protein expression and purification is essential. Experience with biochemical and biophysical analysis of proteins and RNA isolation and preparation, and/or current molecular biology methods is a plus.
There will be much more to come throughout 2023, and we are looking forward to beginning the year with the BrisEngBio Annual meeting, and BrisEngBio Connect Partnership and Networking Event.
Ben Hardy, a Research Associate in the School of Biochemistry at the University of Bristol, won a prize for his poster at the Synthetic Biology UK conference (7-8 November 2022).
Summarising work from his PhD, Ben’s poster (Computational Design of a de novo Transmembrane Cytochrome) highlights the successful design of an artificial protein capable of electron transport within membranes – such a protein is an essential component for constructing novel bioenergetic complexes within cells.
This was Ben’s second poster success this year – he won first prize at the Advances in Protein Folding, Evolution & Design conference (April 2022) for the poster: ‘Computational design of Bioenergetic Membrane Proteins’ (pictured).
Red blood cells that have been grown in a laboratory have now been transfused into another person in a world first clinical trial led by a UK team including University of Bristol researchers.
This is the first time in the world that red blood cells that have been grown in a laboratory have been given to another person as part of a trial into blood transfusion.
If proved safe and effective, manufactured blood cells could in time revolutionise treatments for people with blood disorders such as sickle cell and rare blood types. It can be difficult to find enough well-matched donated blood for some people with these disorders.
The trial is studying the lifespan of the lab grown cells compared with infusions of standard red blood cells from the same donor. The lab-grown blood cells are all fresh, so the trial team expect them to perform better than a similar transfusion of standard donated red cells, which contains cells of varying ages.
Additionally, if manufactured cells last longer in the body, patients who regularly need blood may not need transfusions as often. That would reduce iron overload from frequent blood transfusions, which can lead to serious complications.
The trial is the first step towards making lab grown red blood cells available as a future clinical product. For the foreseeable future, manufactured cells could only be used for a very small number of patients with very complex transfusions needs. NHSBT continues to rely on the generosity of donors.
Two people have so far been transfused with the lab-grown red cells. They were closely monitored and no untoward side effects were reported. They are well and healthy. The identities of participants infused so far are not currently being released, to help keep the trial ‘blinded’.
The amount of lab grown cells being infused varies but is around 5-10mls – about one to two teaspoons.
Donors were recruited from NHSBT’s blood donor base. They donated blood to the trial and stem cells were separated out from their blood. These stem cells were then grown to produce red blood cells in a laboratory at NHS Blood and Transplant’s Advanced Therapies Unit in Bristol. The recipients of the blood were recruited from healthy members of the National Institute for Health and Care Research (NIHR) BioResource.
A minimum of ten participants will receive two mini transfusions at least four months apart, one of standard donated red cells and one of lab grown red cells, to find out if the young red blood cells made in the laboratory last longer than cells made in the body.
Further trials are needed before clinical use, but this research marks a significant step in using lab grown red blood cells to improve treatment for patients with rare blood types or people with complex transfusion needs.
Co-Chief Investigator Ashley Toye, Professor of Cell Biology at the University of Bristol and Director of the NIHR Blood and Transplant Unit in red cell products, said: “This challenging and exciting trial is a huge stepping stone for manufacturing blood from stem cells. This is the first-time lab grown blood from an allogeneic donor has been transfused and we are excited to see how well the cells perform at the end of the clinical trial.”
Co-Chief Investigator Cedric Ghevaert, Professor in Transfusion Medicine and Consultant Haematologist the University of Cambridge and NHS Blood and Transplant, said: “We hope our lab grown red blood cells will last longer than those that come from blood donors. If our trial, the first such in the world, is successful, it will mean that patients who currently require regular long-term blood transfusions will need fewer transfusions in future, helping transform their care.”
Dr Rebecca Cardigan, Head of Component Development NHS Blood and Transplant and Affiliated Lecturer at the University of Cambridge said: “It’s really fantastic that we are now able to grow enough red cells to medical grade to allow this trial to commence, we are really looking forward to seeing the results and whether they perform better than standard red cells.”
John James OBE, Chief Executive of the Sickle Cell Society, said: “This research offers real hope for those difficult to transfuse sickle cell patients who have developed antibodies against most donor blood types. However, we should remember that the NHS still needs 250 blood donations every day to treat people with sickle cell and the figure is rising. The need for normal blood donations to provide the vast majority of blood transfusions will remain. We strongly encourage people with African and Caribbean heritage to keep registering as blood donors and start giving blood regularly.”
Dr Farrukh Shah, Medical Director of Transfusion for NHS Blood and Transplant, said: “Patients who need regular or intermittent blood transfusions may result develop antibodies against minor blood groups which makes it harder to find donor blood which can be transfused without the risk of a potentially life-threatening reaction. This world leading research lays the groundwork for the manufacture of red blood cells that can safely be used to transfuse people with disorders like sickle cell. The need for normal blood donations to provide the vast majority of blood will remain. But the potential for this work to benefit hard to transfuse patients is very significant.”
Zentraxa, founded on IP generated through BrisSynBio, specialises in the design, production and testing of novel biomaterials. It has received £320k funding for commercial concept development of both medical adhesives and personal care ingredients that could have use in medicine, for example, skin bonding and wound care, or in personal use, such as skin and hair products.
Glaia, which benefitted from BrisSynBio commercialisation funding and dedicated innovation support, has secured £1 million in new investment to develop its carbon-based technology, the ‘sugar dots’, which increases crop yields and reduces emissions from crops by 30% when applied to the plants.
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